Vertisal (Metronidazole)

Active Ingredient: Metronidazole
Dosage: 180 ml
Route of Administration: Oral
Dosage Form: Suspension
Quantity per package: 1 unit
Availability: Out of stock

Vertisal is an antibiotic from the group of nitroimidazoles that is used to treat certain infections caused by bacteria and other organisms in different parts of the body. The drug is also used to prevent or treat certain infections that may occur during surgery. This suspension kills or stops the growth of bacteria and other organisms causing infections. The active ingredient of Vertisal suspension is Metronidazole. This antibiotic is out of stock, currently. By the way, every customer may find a proper antibiotic surfing our category.

Indications

The oral suspension – Vertisal (Metronidazole) is indicated in the treatment of:

• acute or chronic intestinal invasive amebiasis;
• amebic liver abscess;
• other forms of invasive extraintestinal amebiasis;
• giardiasis;
• vaginitis;
• urethritis due to Trichomonas and/or Gardnerella.

Dosage and administration

• Adult amebiasis: 1,200 to 2.0 g in 24 hours for 7 to 10 days; maximum dose per day 2.5 g.
• Childhood amebiasis: Depending on age, the dose varies from 30 to 40 mg/kg / 24 hours for 7 to 10 days.
• Amebic liver abscess: The average dose is 1.5 to 2 g of metronidazole in 24 hours for 10 days. It can be combined with the parenteral route.
• Vaginitis and/or urethritis due to Trichomonas and/or Gardnerella: From 1,200 to 2.0 g / day for 10 days. Children: 20 mg/kg/day for 7 days.
• Giardiasis: In adults 3 capsules (1,200 g) per day for 5-7 days.
• In children, 20 mg / kg / day divided into 3 doses for 5 consecutive days.
• Anaerobic infections: The presentation is recommended for parenteral application at the start of therapy and change to the oral route when the patient’s conditions improve.

Contraindications

• Pregnancy;
• Lactation;
• Hypersensitivity;
• Ingestion of alcoholic beverages;
• Active CNS conditions;
• Blood dyscrasia;
• Severe liver failure.

Side effects

• Nausea;
• Vomiting;
• Metallic and unpleasant taste in the mouth;
• Headache;
• Diarrhea;
• Dizziness;
• Rash;
• Pruritus.

At high doses, there are the following side effects:

• fever;
• erythema;
• leukopenia;
• seizures;
• peripheral neuropathy.

If alcoholic beverages are ingested, there is a disulfiram reaction characterized by:

• face redness;
• headache;
• occasionally lowering of blood pressure.

All these undesirable reactions disappear at the end of therapy or its discontinuation.

Overdose

Doses of 6,000 to 10,400 mg cause nausea, vomiting and ataxia, seizures and peripheral neuropathy. There is no specific antidote.

In the case of oral administration, it is recommended to cause vomiting and conduct general measures together with symptomatic therapy.

Interaction

Vertisal potentiates warfarin and coumarin anticoagulants. Barbiturates accelerate the excretion of metronidazole, which can cause therapeutic failures. Cimetidine increases metronidazole concentrations.

Disulfiram is not compatible with metronidazole because acute psychosis or confusional states occur. Metronidazole causes alcohol intolerance as it interferes with your metabolism, it causes a reaction similar to that produced by disulfiram.