Proxalin (Naproxen, Acetaminophen)

Active Ingredient: Naproxen, Acetaminophen
Dosage: 300 mg/250 mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 16 tablets per pack
Availability: Out of Stock

Why is Proxalin not used in the USA?

Proxalin is not used in the USA, likely due to regulatory reasons or specific FDA approval challenges related to the combination of Naproxen and Acetaminophen. The U.S. has stringent regulations on combination drugs, requiring detailed evidence of safety and efficacy, which can be a barrier to entry for certain pharmaceuticals.

Alternatives Available in the USA

Here are some alternatives available in the USA, categorized by their use for similar conditions as Proxalin:

Arthritis and Ankylosing Spondylitis

Tendinitis and Bursitis

Gout

Menstrual Cramps

Each of these alternatives in the U.S. has its own specific usage, active ingredients, and mechanisms of action suited for similar conditions as those treated by Proxalin. They are widely used and available, following FDA approval, ensuring their safety and efficacy for the prescribed conditions.

What is Proxalin?

Proxalin is classified as a nonsteroidal anti-inflammatory drug (NSAID) that contains both Naproxen and Acetaminophen and works by reducing inflammation and pain in the body. The drug is used in arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps. The dual action of Naproxen and Acetaminophen helps in reducing inflammation and providing analgesic relief, making it effective for these conditions.

Indications

Proxalin is promarily used to treat:

Symptomatic treatment of pain and fever, as a complement to antibiotic therapy in respiratory tract infections;
Moderate osteomuscular pain, otalgia, headache, postoperative and postpartum pain, in oropharyngeal surgery, dental pain and traumatic pain.

Popularity and Usage in Other Countries

Proxalin is popular in several countries, including Mexico, particularly where there may be fewer restrictions on combination drugs or where these specific pain conditions are prevalent. Its usage tends to be higher in countries with larger aging populations suffering from chronic conditions like arthritis, or in regions with specific health challenges that lead to conditions treatable by Proxalin.

Dosage and administration

Recommended dosage for adults: Two tablets as the start of treatment and then one tablet every 6 to 8 hours until control of symptoms is obtained.

The typical dosages of Proxalin can vary based on the severity of the condition, but it is generally prescribed in doses that balance effectiveness with minimizing potential side effects. Specific dosage recommendations would typically be made by a healthcare provider.

Contraindications

Hypersensitivity to naproxen and / or paracetamol;
Patients whose acetylsalicylic acid or other non-steroidal analgesic / antipyretic / anti-inflammatory agents have caused asthmatic syndromes, rhinitis or urticaria;
It should not be used in patients who are treated with oral anticoagulants, hepatic and / or renal insufficiency, granulocytopenia, acute gastritis or duodenal ulcer, anemia and cyanotic conditions.

Side effects

In rare cases, Proxalin can cause abdominal discomfort, epigastric discomfort, nausea, headache, tinnitus, vertigo and peripheral edema, mild drowsiness, anemia, agranulocytosis, thrombocytopenia, skin rashes, glossitis, neutropenia, pancytopenia, leukopenia, methemoglobinemia, urticaria, vomiting and mucosal lesions.

Overdose

Symptoms of naproxen overdose are drowsiness, heartburn, indigestion, nausea, vomiting and rarely seizures. Paracetamol in massive doses can cause liver damage in some patients. It is necessary to perform gastric lavage and apply the conventional management of drug intoxication.

Interaction

Patients who are taking hydantoins should take into account that naproxen binds to plasma proteins, so it is sometimes necessary to adjust the dose. It has been reported that this drug can inhibit the natriuretic effect of furosemide and increase the plasma concentration of lithium. Nonsteroidal anti-inflammatory agents may reduce the antihypertensive effect of propranolol and other β-blockers.

Naproxen can significantly increase plasma levels and the half-life of probenecid.