Clendix (Clindamycin)

Active Ingredient: Clindamycin
Dosage: 300 mg
Route of Administration: Oral
Dosage Form: Capsules
Quantity per package: 21
Availability: Out of stock

Why is Clendix not used in the USA?

Clendix itself as a brand is not used in the USA, likely because there are many alternative brands and generic versions of Clindamycin available, and branding preferences can vary by region due to marketing and distribution agreements.

Similar Clendix Drugs Available in the USA

Here’s the list of similar drugs available in the USA to Clindamycin (Clendix), subdivided based on the types of diseases and symptoms they commonly treat:

Skin and Soft Tissue Infections

Respiratory Tract Infections

Urinary Tract Infections

What is Clendix?

Clendix is an antibiotic that inhibits the growth of bacteria. It is used to treat serious infections caused by sensitive microorganisms: pneumonia caused by Staphylococcus aureus, aspiration pneumonia, empyema, pulmonary abscess, acute pharyngotonsillitis caused by streptococcus of group A, odontogenic infections, skin and soft tissue infections (complicated and uncomplicated), osteomyelitis, pneumonia caused by Pneumocystis jiroveci (Pneumocystis carinii) in patients with HIV infection, toxoplasmic encephalitis in patients with HIV infection.

Indications

• Infectious and inflammatory diseases caused by microorganisms sensitive to clindamycin;
• Upper respiratory tract infections and infections of ENT organs (pharyngitis, tonsillitis, sinusitis, otitis media), lower respiratory tract infections (pneumonia, including aspiration, lung abscess, pleural empyema, bronchitis), scarlet fever, diphtheria;
• Infections of the urogenital tract (chlamydia, endometritis, vaginal infections, tubo-ovarian inflammation);
• Infections of the skin and soft tissues (infected wounds, abscesses, boils, panaritium), abdominal cavity (peritonitis, abscess), oral cavity;
• Acute and chronic osteomyelitis;
• Septicemia (primarily anaerobic);
• Bacterial endocarditis;
• Prevention of peritonitis and intra-abdominal abscesses after perforation of the intestine or as a result of traumatic infection (in combination with aminoglycosides).

Dosage and administration

Oral administration. 1 capsule (150 mg) 4 times/day (every 6 hours) is prescribed for adults and children over 15 years of age (average child weight of 50 kg and above) for diseases of moderate severity.

In severe infections, adults and children over 15 years of age, a single dose can be increased to 2-3 capsules (300-450 mg).

Children over 3 years old – 15-25 mg/kg/day, divided into 3-4 equal doses. In severe infections, the daily dose can be increased to 25-40 mg/kg body weight, divided into 3-4 injections.

Popularity and Use in Specific Countries

Clendix is popular in several countries across Latin America, including Mexico and some South American countries, due to its effectiveness against a variety of infections and its availability as a generic, which makes it more affordable. It is widely used to treat infections where the causative organisms are susceptible to clindamycin, and where other antibiotics might not be as effective due to resistance or patient allergies.

Contraindications

The main contraindications caused by Clendix are:

• myasthenia gravis;
• bronchial asthma;
• ulcerative colitis (in the anamnesis);
• rare hereditary diseases, such as: galactose intolerance, lactase deficiency or glucose-galactose malabsorption (for capsules);
• pregnancy;
• lactation period;
• children’s age up to 3 years – for a solution for intravenous and intramuscular administration (due to the lack of safety data on the use of benzyl alcohol);
• children’s age up to 8 years for capsules (average child weight less than 25 kg);
• hypersensitivity.

Clendix is used with caution in patients with severe hepatic and/or renal failure, in elderly patients.

Side effects

• Digestive system: dyspepsia (abdominal pain, nausea, vomiting, diarrhea), esophagitis, jaundice, impaired liver function, hyperbilirubinemia, dysbiosis, pseudomembranous enterocolitis.
• Musculoskeletal system: rarely – a violation of neuromuscular conduction.
• Hemopoietic organs: leukopenia, neutropenia, agranulocytosis, thrombocytopenia.
• Allergic reactions: rarely – maculopapular rash, urticaria, itching; in some cases, exfoliative and vesiculobullous dermatitis, eosinophilia, anaphylactoid reactions.
• Cardiovascular system: with rapid on/in the introduction – a decrease in blood pressure, up to collapse; dizziness, weakness.
• Local reactions: irritation, soreness (at the site of intramuscular injection), thrombophlebitis (at the site of intravenous injection).
• Other: development of superinfection.

Overdose

In case of an overdose, side effects may intensify.

Treatment: symptomatic therapy. There is no specific antidote. Hemodialysis and peritoneal dialysis are ineffective.

Interaction

• Clendix (Clindamycin) enhances the (mutually) effect of rifampicin, streptomycin aminoglycosides, gentamicin (especially in the treatment of osteomyelitis and the prevention of peritonitis after intestinal perforation).
• It enhances the effect of competitive muscle relaxants and also improves the muscle relaxation caused by n-anticholinergics.
• It is incompatible with ampicillin, barbiturates, aminophylline, calcium gluconate, and magnesium sulfate.
• It is also non-combinable with erythromycin and chloramphenicol.
• The simultaneous use with solutions containing a complex of B vitamins, aminoglycosides, phenytoin is not recommended.
• Simultaneous administration with antidiarrheal drugs increases the risk of pseudomembranous colitis.
• Simultaneous use with opioid (narcotic) analgesics possibly increases the respiratory depression caused by them (up to apnea).