Afumix (Fluconazole, Tinidazole)

Active Ingredient: Fluconazole, Tinidazole
Dosage: 37.5 mg/500 mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 4 tablets per pack
Availability: Out of stock

Non-Usage in the USA

Afumix is not used in the USA primarily because of the availability of alternative medications that are already approved by the FDA and widely used in the healthcare system. American guidelines might also prefer other established combinations or single-agent treatments for the types of infections Afumix treats.

Similar Drugs Available in the USA

Since Afumix combines an antifungal and an antibiotic, similar treatments available in the USA typically include separate medications for fungal and bacterial infections. Here are some options from your initial list that are used for similar diseases and symptoms:

Antifungal Medications:

Antibacterial/Antiprotozoal Medications:

Off-label usage for fungal infections:

What is Afumix?

Afumix is a combination of fluconazol and tinidazol. It is a broad-spectrum antibiotic that is used to fight vaginal infections. It is indicated in bacterial infections, fungi and parasites, mixed vaginal infections caused by trichomonas, Candida, Gardnerella vaginalis and anaerobic bacteria.

Indications

Afumix is a broad-spectrum antifungal that is indicated in mixed vaginal infections caused by Candida, trichomonas, Gardnerella vaginalis and anaerobic bacteria.

Dosage and administration

The drug is taken orally. The recommended dose is 2 tablets every 12 hours for a day or 4 tablets together as a single dose. The exact dosage might vary based on the severity of the infection and the prescribing doctor’s guidance.

Popularity and Use in Specific Countries

Afumix is popular in countries with higher prevalence rates of mixed and complex vaginal infections, particularly in regions like Latin America. These countries might have higher incidences of these infections due to various socioeconomic factors, including access to healthcare and public health education.

Contraindications

Patients with blood dyscrasias, neurological disorders of the organic type, known hypersensitivity to the drug or other compounds of the azole group, terfenadine.

Side effects

Afumix is well tolerated; however, nausea, vomiting, anorexia, abdominal pain, diarrhea, flatulence and metallic taste may occur. Cutaneous rash, pruritus, urticaria and angioneurotic edema have also been reported, so treatment should be discontinued if bulosic lesions or erythema multiforme develop.

Overdose

In overdose, symptomatic treatment with supportive measures and gastric lavage is recommended; if necessary, a forced diuresis will increase the elimination rate. A hemodialysis session lasting 3 hours lowers plasma levels by approximately 50%.

Interaction

Fluconazole increases prothrombin time after administration of warfarin in healthy men, so surveillance is recommended in patients receiving coumarin-like anticoagulants. The use of fluconazole prolongs the half-life of sulfonylureas, so you should bear in mind that co-administration may cause hypoglycemia. Coadministration with multiple doses of hydrochlorothiazide increases fluconazole plasma concentrations by 40%, without requiring a change in the fluconazole dosage schedule. Coadministration of fluconazole and phenytoin may increase levels of the latter. Coadministration of fluconazole and rifampicin reduced the half-life of fluconazole. The coadministration of fluconazole and theophylline affects the clearance of the latter. Coadministration of fluconazole with terfenadine at a dose of 400 mg or more results in an increase in the plasmatic levels of terfenadine. Concomitant use with cisapride may cause cardiac alterations, with rifabutin, tacrolimus and zidovudine – an increase in serum levels. The consumption of alcoholic beverages should be avoided as it can cause a disulfiram reaction.